Nigel J Cairns Selected Research

alpha-internexin

5/2006	Mutation analysis of patients with neuronal intermediate filament inclusion disease (NIFID).
10/2005	Neuronal intranuclear inclusions are ultrastructurally and immunologically distinct from cytoplasmic inclusions of neuronal intermediate filament inclusion disease.
9/2004	alpha-Internexin aggregates are abundant in neuronal intermediate filament inclusion disease (NIFID) but rare in other neurodegenerative diseases.
6/2004	alpha-internexin is present in the pathological inclusions of neuronal intermediate filament inclusion disease.

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Nigel J Cairns Research Topics

Disease

78	Alzheimer Disease (Alzheimer's Disease) 10/2022 - 08/2002
31	Frontotemporal Lobar Degeneration (Degeneration, Frontotemporal Lobar) 01/2019 - 06/2006
21	Frontotemporal Dementia (Semantic Dementia) 01/2019 - 09/2004
20	Dementia (Dementias) 01/2020 - 06/2005
18	Neurodegenerative Diseases (Neurodegenerative Disease) 01/2019 - 08/2002
16	Cognitive Dysfunction 01/2022 - 11/2010
16	Atrophy 01/2021 - 05/2009
15	Tauopathies 01/2021 - 09/2004
12	Parkinson Disease (Parkinson's Disease) 01/2022 - 11/2010
10	Cytomegalovirus Infections (Inclusion Disease) 10/2015 - 06/2004
8	Amyloid Plaque 01/2020 - 06/2005
7	Motor Neuron Disease (Primary Lateral Sclerosis) 01/2018 - 09/2004
7	Gliosis 11/2011 - 03/2003
6	Proteostasis Deficiencies 01/2020 - 01/2008
6	Disease Progression 01/2019 - 11/2007
6	Amyotrophic Lateral Sclerosis (Lou Gehrig's Disease) 01/2018 - 09/2002
6	Sarcoma (Soft Tissue Sarcoma) 12/2012 - 02/2011
5	Progressive Supranuclear Palsy (Steele Richardson Olszewski Syndrome) 01/2021 - 11/2010
5	Amyloidosis 01/2020 - 09/2015
5	Multiple System Atrophy 01/2019 - 01/2004
4	Lewy Body Disease (Lewy Body Dementia) 01/2022 - 08/2005
4	Down Syndrome (Down's Syndrome) 10/2015 - 03/2002
4	TDP-43 Proteinopathies 12/2012 - 07/2007
4	Synucleinopathies 12/2012 - 09/2004
3	Corticobasal Degeneration 01/2021 - 12/2012
3	Neuroinflammatory Diseases 11/2015 - 11/2010
3	Pick Disease of the Brain (Pick's Disease) 10/2015 - 03/2002
3	Prion Diseases (Transmissible Spongiform Encephalopathies) 08/2010 - 06/2005
3	Osteitis Deformans (Paget's Disease of Bone) 05/2009 - 06/2006
3	Muscular Diseases (Myopathy) 05/2009 - 06/2006
2	Parkinsonian Disorders (Parkinsonism) 01/2021 - 12/2011
2	Genetic Risk Score 11/2020 - 01/2020
2	Cerebrovascular Disorders (Cerebrovascular Occlusion) 01/2019 - 06/2013
2	Cerebral Cortical Thinning 01/2018 - 11/2013
2	Sporadic Creutzfeldt-Jakob Disease 10/2015 - 01/2003
2	Creutzfeldt-Jakob Syndrome (Creutzfeldt-Jakob Disease) 10/2015 - 01/2002
2	Hippocampal Sclerosis 01/2012 - 01/2012
2	Cerebrovascular Trauma 01/2012 - 01/2012
1	Cerebral Amyloid Angiopathy (Congophilic Angiopathy) 10/2021
1	Inflammation (Inflammations) 01/2019
1	Chronic Traumatic Encephalopathy 01/2016
1	Lysosomal Storage Diseases (Lysosomal Storage Disease) 11/2015
1	Post-Traumatic Stress Disorders (Post Traumatic Stress Disorder) 07/2015
1	Multiple Sclerosis 07/2015
1	Traumatic Brain Injuries (Traumatic Brain Injury) 07/2015

Drug/Important Bio-Agent (IBA)

41	Amyloid (Amyloid Fibrils)IBA 10/2022 - 10/2003
30	Proteins (Proteins, Gene)FDA Link 01/2022 - 08/2002
29	Biomarkers (Surrogate Marker)IBA 10/2022 - 11/2007
21	DNA-Binding Proteins (DNA Binding Protein)IBA 01/2020 - 02/2007
13	Amyloid beta-PeptidesIBA 11/2020 - 03/2004
13	ProgranulinsIBA 01/2018 - 09/2006
13	UbiquitinIBA 11/2011 - 06/2006
11	Apolipoproteins E (ApoE)IBA 11/2020 - 04/2003
8	Protein AggregatesIBA 12/2017 - 05/2003
6	SynucleinsIBA 01/2022 - 11/2010
6	Microtubule-Associated Proteins (Microtubule-Associated Protein 2)IBA 11/2019 - 10/2003
6	Prion ProteinsIBA 10/2015 - 01/2002
5	2- (4'- (methylamino)phenyl)- 6- hydroxybenzothiazole (Pittsburgh compound B)IBA 10/2021 - 12/2009
5	alpha-SynucleinIBA 11/2020 - 05/2003
5	tau Proteins (tau Protein)IBA 01/2017 - 11/2004
5	Valosin Containing ProteinIBA 05/2009 - 06/2006
4	Pharmaceutical PreparationsIBA 09/2013 - 02/2012
4	RNA-Binding Protein FUSIBA 11/2011 - 02/2011
4	alpha-internexinIBA 05/2006 - 06/2004
3	Indicators and Reagents (Reagents)IBA 01/2021 - 11/2010
3	LipidsIBA 09/2019 - 12/2013
3	PrionsIBA 01/2019 - 10/2014
3	Glucose (Dextrose)FDA LinkGeneric 01/2018 - 11/2013
3	LigandsIBA 12/2017 - 07/2013
3	ApolipoproteinsIBA 12/2016 - 06/2005
3	EpitopesIBA 11/2011 - 09/2004
2	Biological ProductsIBA 01/2020 - 01/2018
2	CytokinesIBA 01/2019 - 10/2003
2	DNA (Deoxyribonucleic Acid)IBA 01/2018 - 11/2009
2	Peptides (Polypeptides)IBA 12/2017 - 01/2013
2	AntibodiesIBA 01/2017 - 03/2003
2	Protein Isoforms (Isoforms)IBA 12/2016 - 10/2003
2	Intermediate Filament ProteinsIBA 02/2011 - 12/2005
2	EnzymesIBA 11/2010 - 08/2003
2	Nicotinic Receptors (Nicotinic Acetylcholine Receptor)IBA 01/2005 - 03/2004
2	Cholinergic Agents (Cholinergics)IBA 01/2005 - 03/2004
2	Cytoskeletal ProteinsIBA 11/2004 - 11/2004
2	Messenger RNA (mRNA)IBA 03/2004 - 08/2003
1	Levodopa (L Dopa)FDA LinkGeneric 01/2021
1	Carrier Proteins (Binding Protein)IBA 01/2019
1	Nerve Growth Factors (Neurotrophins)IBA 01/2019
1	HLA-DQA2 antigenIBA 01/2019
1	Becaplermin (PDGF-BB)FDA Link 01/2019
1	gamma-Aminobutyric Acid (GABA)IBA 12/2018
1	GABA Receptors (GABA Receptor)IBA 12/2018
1	Heterogeneous-Nuclear Ribonucleoproteins (Informatin)IBA 01/2018
1	IsotopesIBA 01/2018
1	BenzothiazolesIBA 12/2017
1	ThiophenesIBA 12/2017
1	7- (6- fluoropyridin- 3- yl)- 5H- pyrido(4,3- b)indoleIBA 11/2017
1	Complement System Proteins (Complement)IBA 01/2017
1	CeroidIBA 11/2015

Therapy/Procedure

10	Therapeutics 01/2021 - 09/2002
2	Deep Brain Stimulation 01/2020 - 12/2011
1	Denervation 01/2017